Research progress of effect and mechanism of protein arginine methyltransferase in tumors

VernacularTitle:蛋白质精氨酸甲基转移酶在肿瘤中的作用及机制研究进展
Author: Jun WEN ; Xuejie MIN ; Li ZHAO ; Xiaoping ZHAO
Keywords: PRMT; methylation; tumor
From: Journal of Shanghai Jiaotong University(Medical Science) 2017;37(6):842-846
CountryChina
Language:Chinese
Abstract: Protein arginine methyltransferase (PRMT) can methylate a variety of proteins,including histones and non-histones,affecting a variety of cellular processes such as transcription,RNA splicing,DNA repair,and cell cycle control.The activity of PRMT is affected by a variety of regulatory mechanisms,and its abnormal expression plays an important role in the development of the diseases,especially in tumors such as breast cancer and leukemia.PRMT has a unique value in the diagnosis or treatment of tumors.With the further exploration of PRMT methylation mechanism,PRMT selective inhibitors have made some progress.PRMT-specific inhibitors are expected to be targeted drugs for the treatment of tumors.