Correlation between Gab2 expression in ovarian cancer and resistance to platinum drugs chemotherapy
10.3969/j.issn.1671-8348.2017.21.015
- VernacularTitle:Gab2在卵巢癌中的表达及其与铂类药物化疗耐药的相关性研究
- Author:
Min FENG
;
Renxin XIN
;
Wei XIN
;
Yuanbin GOU
;
Guangzhi LI
- Keywords:
ovarian neoplasms;
Gab2;
cisplatin;
drug resistance
- From:
Chongqing Medicine
2017;46(21):2931-2933
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between Gab2 expression and platinum drugs chemotherapy resistance by detecting the expression of Gab2 in ovarian cancer.Methods Immunohistochemical and Western blotting techniques were used to detect the expression of Gab2 in 107 specimens of serous ovarian tumor tissue and 12 specimens of normal ovarian tissues resected during bladder cancer radical operation in the department of gynaecology of our hospital from January 2011 to June 2015.The correlation between Gab2 expression with clinical stage and effect of combined chemotherapy based on platinum drugs was analyzed.Results The Gab2 expression level in ovarian cancer tissue was significantly higher than that in normal ovarian tissue,moreover had a relation with the FIGO clinical stage,the expression level of Gab2 increased with the increase of clinical stage,the difference was statistically significant (P<0.05);61 cases were sensitive to chemotherapy,46 cases were resistant to chemotherapy,the Gab2 expression level in the patients with chemotherapy resistance was significantly higher than that in the patients with chemotherapy sensitivity,the difference was statistically significant (P<0.05).Conclusion Gab2 may become one of effective indexes for predicting platinum drugs chemotherapy sensitivity.
