Protective effects of Shuxuening Injection combined with ganglioside on patients with acute severe carbon monoxide poisoning
10.3969/j.issn.1001-1528.2017.07.007
- VernacularTitle:舒血宁注射液联合神经节苷脂对急性重度CO中毒患者的保护作用
- Author:
Jiaqi HE
;
Hongna QI
;
Fantuo KONG
;
Lijuan AN
;
Qingmian XIAO
;
Weizhan WANG
;
Qian LIU
- Keywords:
Shuxuening Injection;
ganglioside;
combined medication;
acute severe carbon monoxide poisoning;
cerebral oxygen utilization coefficient;
lactate clearance rate
- From:
Chinese Traditional Patent Medicine
2017;39(7):1361-1365
- CountryChina
- Language:Chinese
-
Abstract:
AIM To investigate the effects of Shuxuening Injection (Ginkgo biloba extract) combined with ganglioside on cerebral oxygen utilization coefficient (O2UCc) and lactate clearance rate (LCR) in patients with acute severe carbon monoxide poisoning (ASCOP).METHODS Two hundred and sixty-two patients with ASCOP treated in emergency department of Harrison International Peace Hospital Affiliated to Hebei Medical University from Mar 2011 to Mar 2016 were randomly divided into control group,Shuxuening Injection group,ganglioside group and Shuxuening Injection combined with ganglioside (combined medication) group.The changes were detected in oxygen saturations of carotid blood and jugular blood,arterial blood lactic acid,O2UCc and LCR in all patients before and 6,24 hours,3 days after the treatment.The clinical symptoms,and the mortality and morbidity of delayed encephalopathy after acute carbon monoxide poisoning after two weeks were observed.RESULTS Total effective rate of the combined medication group was higher than that of the other groups.O2 Ucc at 6,24 hours after the treatment in the combined medication group were significantly lower than those in the other groups,so did the mortality and morbidity of delayed encephalopathy after acute carbon monoxide poisoning,but LCR was significantly higher than that in the other groups.All the differences had statistical significances.CONCLUSION The efficacy of combined medication of Shuxuening Injection and ganglioside in ASCOP patients is better than that of applying single administration separately.
