Usage and efficacy of timolol maleate eye drops in treatment of superficial infantile hemangioma
10.11817/j.issn.1672-7347.2017.06.010
- VernacularTitle:马来酸噻吗洛尔滴眼液治疗浅表型婴幼儿血管瘤用药方法的探讨
- Author:
Qizhen WU
;
Qingmei SHI
;
Jianhong LONG
;
Jiaguang LI
;
Yu GUO
;
Shaorong LEI
- Keywords:
infantile hemangioma;
propranolol;
timolol maleate eye drops
- From:
Journal of Central South University(Medical Sciences)
2017;42(6):657-661
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To determine drug dose and usage of timolol maleate eye drops in the treatment of superficial infantile hemangioma.Methods:A total of 250 superficial hemangioma infants were recruited and assigned into 5 groups (n=50 for each group):an external application group and 4 exterior coating groups (2,4,6,8 times per day).We evaluated the therapeutic effect of different methods for drug application (external application or exterior coating) and the frequency for drug administration on superficial infantile hemangioma.Results:The external application group (twice a day and 0.5 hour per time) showed better effect than that in the exterior coating group with twice a day (P＜0.001).The difference in therapeutic effect between the exterior coating group with 6 times a day and exterior coating group with twice a day or with 3 times a day was significant (P＜0.001).The differences in drug efficacy were not found among the exterior coating group with 6 times a day,the exterior coating group with 8 times a day,or the external application group with twice a day (All P＞0.05).Conclusion:Drug dose may affect the therapeutic effect oftimolol maleate eye drops in superficial hemangioma infants,and exterior coating with 6 times a day may achieve the best curative effect.
