Progress of microRNAs and B-cell receptor signaling pathway in chronic lymphocytic leukemia

VernacularTitle:微RNA及B细胞受体信号通路在慢性淋巴细胞白血病中的研究进展
Author: Miao SU
Keywords: MicroRNAs; Leukemia; lymphocytic; chronic; B-cell receptor signaling pathway
From: Journal of Leukemia & Lymphoma 2017;26(7):432-436
CountryChina
Language:Chinese
Abstract: Many studies have confirmed that dysregulation of microRNAs (miRNAs) expression can cause disruption of the hematopoietic system and contribute to leukemogenesis by regulating the expression of some oncogenes and anti-oncogenes. Chronic lymphocytic leukemia (CLL) is a malignant proliferative disease of B lymphocytes with significant heterogeneity in the incidence of individuals, disease progression, treatment response and clinical prognosis. The increasing studies have shown that the mutation or abnormal expression of miRNAs is closely related to CLL occurrence, progression, prognosis and curative efficacy. Certain miRNAs are involved in the intricate interplay with B-cell receptor (BCR) signaling pathway. The review discusses the latest progress of miRNAs expression in BCR signaling pathway and CLL onset and progression.