Progress of microRNAs in chronic lymphocytic leukemia
10.3760/cma.j.issn.1009-9921.2017.07.017
- VernacularTitle:微RNA在慢性淋巴细胞白血病中的研究进展
- Author:
Wenhuang XIE
- Keywords:
MicroRNAs;
Leukemia;
lymphocytic;
chronic
- From:
Journal of Leukemia & Lymphoma
2017;26(7):445-448
- CountryChina
- Language:Chinese
-
Abstract:
MicroRNAs (miRNAs), with 19-25 nucleotides in length, are small non-coding single-stranded RNAs and play an important role in a variety of organisms cell growth, differentiation, proliferation and apoptosis, fat metabolism and other physiological processes. Numerous studies have shown that the deregulation of miRNAs was associated with progression, prognosis and drug resistance of chronic lymphocytic leukemia (CLL). MiR-15a/16-1 cluster, miRs-34b/c , miR-181b, miR-29, miR-3676, miR-17/92 and miR-155 family members were the most common deregulated miRNAs in CLL, which could regulate important gene expressions. To further clarify molecular mechanism of occurrence and development of CLL, this review focuses on recent advances on the regulatory networks of related miRNAs as well as the integration with other regulators.
