The application value of monoexponential,biexponential models multiple b values DWI in pancreatic cancer
10.3969/j.issn.1002-1671.2017.07.011
- VernacularTitle:单指数、双指数模型多b值DWI在胰腺癌的应用价值
- Author:
Wanling MA
;
Mengqi WEI
;
Jing REN
;
Jinsong ZHANG
;
Qi PAN
;
Weihuan HOU
;
Guangwen ZHANG
;
Didi WEN
;
Jinman ZHONG
;
Yi HUAN
- Keywords:
pancreatic cancer;
magnetic resonance imaging
- From:
Journal of Practical Radiology
2017;33(7):1024-1028
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the application value of monoexponential, biexponential models multiple b values diffusion weighted imaging(DWI) in distinguishing pancreatic cancer from non-tumorous pancreas.Methods Subjects comprised 37 pancreatic cancers confirmed by clinical or surgery.Pancreas multiple b values DWI was performed using 3.0T scanner.Standard apparent diffusion coefficient (ADCstandard) was calculated using monoexponential diffusion model.Pure diffusion coefficient (ADCslow), pseudodiffusion coefficient (ADCfast) and perfusion fraction (f) were calculated using intravoxel incoherent motion(IVIM) diffusion model.Parameters of pancreatic cancers and non-tumorous pancreas were compared using independent samples t test.Results Mean ADCslow value of pancreatic cancer was higher than that of non-tumorous pancreas (0.611×10-3 mm2/s vs 0.521×10-3 mm2/s,P=0.037).Mean ADCfast and f values of pancreatic cancer were lower than that of non-tumorous pancreas (5.066×10-3 mm2/s vs 7.188×10-3 mm2/s,P=0.035;55.8% vs 64.0%,P=0.016;respectively).ADCslow of pancreatic cancer was positively correlated to ADCstandard (r=0.824,P=0.000).ADCfast of pancreatic cancer was negatively correlated to f(r=-0.558,P=0.000).Conclusion ADCslow, ADCfast and f derived from IVIM-DWI model can distinguish pancreatic cancer from non-tumorous pancreas.IVIM-DWI may be a promising and non-invasive tool for early diagnosing and differentiating pancreatic carcinoma from non-tumorous pancreas.
