Application of DCE-MRI in orthotopic transplantation model of gastric cancer in nude mice
10.3969/j.issn.1002-1671.2017.07.035
- VernacularTitle:DCE-MRI对裸鼠胃癌原位移植瘤的可行性研究
- Author:
Xuelian SHI
;
Gaofeng SHI
;
Qi WANG
;
Hui LIU
;
Jianhua WU
;
Li YANG
;
Jiangyang PAN
;
Ning ZHANG
- Keywords:
dynamic contrast enhanced magnetic resonance imaging;
Ktrans;
gastric cancer;
orthotopic transplantation model;
microvessel density
- From:
Journal of Practical Radiology
2017;33(7):1121-1124
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the feasibility of DCE-MRI application in the orthotopic transplantation model of gastric cancer in nude mice.Methods Orthotopic transplantation model of gastric cancer in nude mice was established, and 15 models underwent DCE-MRI using the contrast agent of gadopentetate.Subsequently, the tumor was dissected in order to detect the MVD.The MVD was compared between orthotopic transplantation tumor model of gastric cancer and normal gastric mucosa.Results Fifteen nude mice with orthotopic transplantation of gastric cancer successfully underwent DCE-MRI examination.As for the cancer, the values of Ktrans, Kep and Ve were (2.11±0.44) min-1, (4.59±0.93) min-1, and 0.46±0.06, respectively.The MVD in gastric cancer tissues was significantly higher than that in normal gastric mucosa (χ2=16.205, P<0.001).Conclusion DCE-MRI can be used for noninvasively quantitative evaluation of vascular parameters of gastric carcinoma.
