Correlation between antimicrobial resistance and antimicrobial use density of Escherichia coli and Klebsiella pneumoniae
10.3969/j.issn.1671-9638.2017.07.004
- VernacularTitle:大肠埃希菌及肺炎克雷伯菌耐药性与抗菌药物使用强度相关性
- Author:
Wei ZHENG
;
Yiping MAO
;
Fangzheng HAN
;
Hong ZHOU
;
Renxu ZHAI
;
Jianmei CAO
;
Xinzhong ZHAO
;
Xinguo JIANG
- Keywords:
Escherichiacoli;
Klebsiellapneumoniae;
antimicrobial agent;
antimicrobial use density;
AUD;
drug resistance
- From:
Chinese Journal of Infection Control
2017;16(7):606-609
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate antimicrobial resistance of Escherichia coli (E.coli)and Klebsiella pneumoniae (K.pneumoniae),antimicrobial use density(AUD),as well as relation between antimicrobial resistance and AUD in a ter-tiary first-class hospital.Methods Antimicrobial resistance rates of clinically-isolated E.coli and K.pneumoniae,AUD of carbapenems and quinolones,as well as relation between resistance and AUD in 2013-2015 were statistically analyzed. Results Correlation analysis of antimicrobial resistance of bacteria and AUD showed that the decrease in resistance rate of E.coli to levofloxacin was related to the decrease in the use density of quinolones(r=0.61,P=0.03);increase in resist-ance rate of K.pneumoniae to imipenem was related to the increase in the use density of carbapenems(r=0.78,P<0.01). Conclusion Antimicrobial use is one of the causes of bacterial resistance,management on antimicrobial use needs to be strengthened to reduce the threat of bacterial resistance to human health.
