Adjuvant chemoradiotherapy for postoperative head and neck squamous cell carcinoma
10.19401/j.cnki.1007-3639.2017.06.011
- VernacularTitle:头颈部鳞癌术后辅助放化疗的研究现状
- Author:
Xueguan LU
;
Chaosu HU
- Keywords:
Head and neck cancer;
Squamous cell carcinoma;
Radiotherapy;
Chemotherapy;
Molecular targeted therapy
- From:China Oncology
2017;27(6):463-470
- CountryChina
- Language:Chinese
-
Abstract:
Emerging clinical evidence revealed that postoperative adjuvant chemoradiotherapy (CRT) could improve the clinical outcome for resected head and neck squamous cell carcinoma in high-risk patients. The irradiation targets and doses should be determined by the primary tumor site, clinical stage, pathology reports, and the evaluation of postoperative imaging. Adjuvant concurrent CRT with cisplatin is the current standard treatment for high-risk postoperative head and neck squamous cell carcinoma patients. However, the effect of concurrent CRT with other chemotherapeutic agents and (or) epidermal growth factor receptor (EGFR) monoclonal antibody in these patients is inconclusive. Human papillomavirus (HPV)-positive oropharyngeal cancer has the unique biological characteristics, and the indications and treatment models of postoperative adjuvant CRT for these patients are still unclear. Further study is needed.
