Role of myeloid-derived suppressor cells in premetastatic niche formation and tumor metastasis promotion
10.19401/j.cnki.1007-3639.2017.06.020
- VernacularTitle:髓源性抑制细胞在构筑转移前微环境促肿瘤转移中的作用
- Author:
Huamin WEI
- Keywords:
Myeloid-derived suppressor cells;
Premetastatic niche;
Tumor metastasis
- From:China Oncology
2017;27(6):516-520
- CountryChina
- Language:Chinese
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Abstract:
Sustaining survival of tumor cells is the main limiting step of tumor metastasis. Similar to tumor microenvironment, local environment in premetastatic organ (premetastatic niche) also provides a favorable condition for surviving of tumor cell and is the premise of tumor cell survival and proliferation in distant organ. Myeloid-derived suppressor cells (MDSCs) are the key component of the niche and play an important role in tumor cell implantation and metastasis formation through fabricating a proliferative, inflammatory, immunosuppressive and vascular remodeling premetastatic niche. MDSCs may also serve as potential therapeutic target for anti-metastasis therapy. Here, this study focused on the mechanisms of MDSCs in prematastatic niche formation and associated signal pathway, moreover, pro-vided reference to study on anti-metastasis therapy through interfering with the formation of premetastatic niche.
