Comparison of Therapeutic Efficacy of Different Administration Routes of Ambroxol in the Treatment of Pediatric Respiratory Disease
10.6039/j.issn.1001-0408.2017.20.20
- VernacularTitle:氨溴索不同给药途径治疗小儿呼吸系统疾病的疗效比较
- Author:
Zhenzhu FU
;
Zhuangchan MO
;
Ying PENG
- Keywords:
Ambroxol;
Pediatric;
Respiratory disease;
Atomization inhalation;
Intravenous dripping;
Route of administration
- From:
China Pharmacy
2017;28(20):2807-2809
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the optimal administration route of ambroxol in the treatment of pediatric respiratory disease. METHODS:Totally 120 children with respiratory disease in pediatric department of our hospital during Jun. 2014-Jun. 2016 were divided into intravenous dripping group and atomization inhalation group according to even and odd-numbered admission order,with 60 cases in each group. Intravenous drip group was given Ambroxol hydrochloride injection 7.5 mg dissolved in 5%glucose solution 50 mL,ivgtt,bid;aerosol inhalation group was given aerosol inhalation of Ambroxol hydrochloride injection 7.5 mg,for 15 min each time,bid. The two groups were treated with 7 d. Clinical efficacies,p(O2)and p(CO2)level,the times of sputum absorption,clinical indexes and the occurrence of ADR were compared between 2 groups. RESULTS:Total response rate of atomization inhalation group(96.67%)was significantly higher than intravenous dripping group(78.33%);p(O2)level was sig-nificantly higher than intravenous dripping group,while the times of sputum absorption,fever disappearance time,asthma disap-pearance time,oxygen therapy time,pulmonary rales disappearance time,cough disappearance time and average hospitalization time were significantly less or shorter intravenous dripping group,with statistical significance (P<0.05). There was no statistical significance in p(CO2) level and the incidence of ADR between 2 groups (P>0.05). CONCLUSIONS:Ambroxol is effective in the treatment of pediatric respiratory disease,and clinical efficacy of atomization inhalation is better than intravenous drop.
