Clinical Observation of Tiotropium Bromide Assisted with Bronchoalveolar Lavage for Bronchiectasis Com-plicated with Lung Infection
10.6039/j.issn.1001-0408.2017.20.22
- VernacularTitle:噻托溴铵辅助支气管肺泡灌洗用于支气管扩张合并肺部感染的临床观察
- Author:
Youhuan HUANG
;
Ruiguang WANG
;
Zhiliang LI
- Keywords:
Tiotropium bromide;
Bronchoalveolar lavage;
Bronchiectasis;
Lung infection;
Lung function;
Quality of life;
Re-hospitalization rate
- From:
China Pharmacy
2017;28(20):2813-2816
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the effects of tiotropium bromide assisted with bronchoalveolar lavage (BAL) on short-term efficacy,quality of life and re-hospitalization rate of patients with bronchiectasis complicated with lung infection. METH-ODS:A total of 140 patients with bronchiectasis complicated with lung infection selected from our hospital during Oct. 2013-Dec. 2015 were divided into control group and observation group by lottery,with 70 cases in each group. Based on intervention therapy, control group received BAL. Observation group was additionally given Tiotropium bromide powder inhalation 18 μg ,once a day before going to bed,on the basis of control group. Both groups were treated for 4 weeks. Clinical efficacy was compared between 2 group;pulmonary ventilation function indexes,blood gas analysis indexes,BODE index scores and QLI scores before and after treatment,re-hospitalization rate and the occurrence of ADR were also compared between 2 groups. RESULTS:The total response rate of observation group was 91.43%,which was significantly higher than that of control group(78.57%),with statistical signif-icance (P<0.05). Before treatment,there was no statistical significance in pulmonary ventilation function indexes,blood gas analysis indexes,BOED index scores or QLI scores between 2 groups(P>0.05). After treatment,FVC,FEV1,FEV1%,p(O2) and QLI score of 2 groups were increased significantly,while p(CO2)and BODE index scores were decreased significantly,com-pared to before treatment;all indexes of the observation group was significantly better than the control group,with statistical sig-nificance (P<0.05). The re-hospitalization rate of observation group 3,6 months after treatment was significantly lower thanthat of control group,with statistical significance(P<0.05). No ADR was found in 2 groups. CONCLUSIONS:For patients with bronchiectasis complicated with lung infection,tiotropium bromide assisted with BAL can effectively relieve the clinical symp-toms and signs,improve lung ventilation function and the quality of daily life and can be helpful to reduce the risk of re-hospital-ization with good safety.
