Effects of Preoperative Application of Tirofiban on Related Indexes of Patients with Acute Myocardial In-farction
10.6039/j.issn.1001-0408.2017.20.25
- VernacularTitle:PCI术前应用替罗非班对急性心肌梗死患者相关指标的影响
- Author:
Jingrui LI
;
Yuting LI
- Keywords:
Tirofiban;
Acute myocardial infarction;
Percutaneous coronary intervention;
Myocardial perfusion
- From:
China Pharmacy
2017;28(20):2823-2826
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To observe the effects of preoperative application of tirofiban on related indexes of patients with acute myocardial infarction. METHODS:In retrospective analysis,128 patients with acute myocardial infarction selected from our hospital during Jan. 2015-Jun. 2016 were divided into observation group (76 cases) and control group (52 cases) according to whether or not the tirofiban was used before PCI. Control group was given Aspirin enteric-coated tablets 300 mg,po+ Clopidogrel sulfate tablets 600 mg,po,before PCI,and given Heparin sodium injection 100 U/kg ,iv,during PCI. Observation group was ad-ditionally given Tirofiban hydrochloride injection 0.2 μg/(kg·min),iv,before PCI,on the basis of control group. ST-segment depres-sion and chest pain remission of 2 groups were observed after PCI. CK-MB level before surgery,CK-MB peak value,the time of CK-MB reaching the peak value,duration after surgery as well as TIMI blood flow grading after surgery were also observed in 2 groups. The levels of von Willebrand factor(vWF),ET-1 and NO were observed before and after surgery;the occurrence of ADR was recorded. RESULTS:After PCI,ST-segment depression rate(89.74%)of observation group was significantly higher than that (67.31%)of control group,the chest pain remission rate(89.47%)was significantly higher than that of control group(75.00%), the patients with TIMI blood flow grading grade 2-3 in observation group was more than control group,with statistical significance (P<0.05). Before PCI,there was no statistical significance in the levels of CK-MB,vWF,ET-1 and NO between 2 groups(P>0.05). After PCI,CK-MB peak value,the time of CK-MB reaching the peak value,duration in observation group were significant-ly lower or shorter than control group;the levels of vWF and ET-1 significantly decreased,while NO levels increased;the improve-ment of vWF,ET-1 and NO in observation group was significantly better than control group,with statistical significance (P<0.05). The incidence of mild bleeding in observation group was significantly lower than control group,while the incidence of mod-erate bleeding was significantly higher than control group,with statistical significance (P<0.05). There was no statistical signifi-cance in the incidence of death between 2 groups(P>0.05). CONCLUSIONS:The application of tirofiban before PCI can relieve clinical symptom,improve cardiac function,protect vascular endothelial and restore coronary artery perfusion. The attention should be paid to the risk of bleeding.
