Correlation between FA value and α-SMA of renal tissue in patients with chronic kidney disease
10.3969/j.issn.1002-1671.2017.07.018
- VernacularTitle:慢性肾脏病肾组织FA值与a-SMA表达的相关性研究
- Author:
Junli LU
;
Jin ZHU
;
Jian ZHAO
;
Hong YU
;
Xiaohui MA
;
Wei ZHANG
;
Ying LI
- Keywords:
chronic kidney disease;
magnetic resonance imaging;
diffusion tensor imaging;
fraction anisotropy;
α-SMA
- From:
Journal of Practical Radiology
2017;33(7):1056-1058
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the correlation between fractional anisotropy(FA) value and α-SMA of renal tissue in patients with chronic kidney disease (CKD).Methods 33 CKD patients underwent MRI standard scanning and diffusion tensor imaging(DTI).FA values were measured on both medulla and cortex of bilateral kidneys on the FA map.24 patients were performed renal biopsy to detect the expression of α-SMA.The integrated optical density of positive-staining region was calculated for each view.The relationship between the FA values and the integrated optical densities of α-SMA was analyzed by using Bivariate correlation analysis.Results There was a significant negative correlation between the cortical FA values and the integrated optical densities of α-SMA (P=0.001).There was a significant negative correlation between the medullary FA values and the integrated optical densities of α-SMA (P=0.035).Conclusion FA value of DTI was correlated with α-SMA of renal tissue in patients with CKD.
