Prognostic value of preoperative neutrophil lymphocyte ratio in patients with gastrointestinal stromal tumors
10.3760/cma.j.issn.1007-631X.2017.07.003
- VernacularTitle:术前中性粒细胞与淋巴细胞比值对胃肠道间质瘤患者预后的预测价值
- Author:
Hui CHEN
;
Mingdong LU
;
Zhaoyi CHEN
;
Tianye HU
;
Zhichao YAO
;
Qing YANG
;
Zhiqiang ZHENG
- Keywords:
Gastrointestinal stromal tumors;
Granulocytes;
Lymphocytes;
Prognosis
- From:
Chinese Journal of General Surgery
2017;32(7):557-560
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the prognostic value of preoperative neutrophil lymphocyte ratio (NLR) in patients with gastrointestinal stromal tumors (GIST).Methods The clinical-pathological data from 85 GIST cases were collected from the Second Affiliated Hospital of Wenzhou Medical University and retrospectively analyzed from June 2009 to December 2013.According to the exclusion criteria,79 cases were enrolled.Preoperative neutrophil and lymphocyte count was collected and NLR was calculated.According to the receiver operating characteristic (ROC) curve of NLR,GIST patients were divided into low NLR group (NLR ＜ 2.30) and high NLR group (NLR ≥ 2.30).Clinic-pathological features and five year disease free survival (DFS) were compared between the two groups.Results There was a statistical significant difference in tumor size and tumor risk between high NLR group and low NLR group (respectively,x2 =9.517,12.411,all P ＜ 0.05).Univariate analysis showed that the five year disease free survival rate of low NLR and high NLR group were 78％ and 32％ (x2 =18.749,P =0.000).By multivariate analysis a high NLR was identified as an independent risk factor of poorer prognosis for patients with GISTs (RR:3.516,95％CI:1.453-8.506,P=0.005).Conclusion A high preoperative NLR is an independent risk factor for the prognosis of GISTs.
