Relationship of MyD88 rs7744 Polymorphism with the Risk and Severity of Coronary Artery Disease
10.12007/j.issn.0258?4646.2017.06.009
- VernacularTitle:髓样分化因子88基因rs7744多态性与冠状动脉粥样硬化性心脏病易感性及严重程度的关系
- Author:
Dandan SUN
;
Yupeng WU
;
Wen LIU
;
Hong YAN
;
Honghu WANG
;
Jun YANG
- Keywords:
coronary artery disease;
disease risk or susceptibility;
modified Gensini score;
myeloid differentiation factor 88;
polymor?phism
- From:
Journal of China Medical University
2017;46(6):519-523
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association between rs7744 polymorphism in the 3'?untranslated region(3'?UTR)of myeloid differen?tiation factor 88(MyD88)gene and the risk and severity of coronary artery disease(CAD)in a North Chinese Han population. Methods The CAD and control groups consisted of 540 patients and 270 subjects,respectively. The genotypes of rs7744 were detected by polymerase chain reac?tion?restriction fragment length polymorphism(PCR?RFLP),and clinical data were collected. Results The distributions of MyD88 rs7744 were in HWE(P>0.1). In the<50?year?old age group,a lower risk of CAD was observed for subjects carrying the variant AG genotype in comparison to subjects carrying the wild AA genotype(OR=0.38,95%CI:0.17-0.93,P=0.029). The MyD88 rs7744 polymorphism was also related to the modified Gensini score(P=0.011),which was lower in subjects carrying the variant GG genotype than the wild AA genotype(5.23±3.85 vs 7.49± 4.96). Conclusion Our results revealed that MyD88 rs7744 polymorphism in the 3'?UTR is correlated with the risk and severity of CAD.
