Efficacy of Evening Medication of Valsartan on Blood Pressure and Renal Function in Patients With Abnormal Nocturnal Blood Pressure
10.3969/j.issn.1000-3614.2017.05.009
- VernacularTitle:苯磺酸氨氯地平联合缬沙坦夜间给药对夜间高血压患者的疗效及肾功能的影响
- Author:
Qinwei XU
;
Zhexun LIAN
- Keywords:
Hypertension;
Antagonists,angiotensin receptor;
Antagonists,channel blocker
- From:
Chinese Circulation Journal
2017;32(5):457-460
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore the efficacy of evening medication of amlodipine combining valsartan on blood pressure (BP) and renal function in patients with abnormal nocturnal blood pressure. Methods: A total of 87 abnormal nocturnal BP patients without ideal efficacy by 4 weeks amlodipine therapy were randomly divided into 2 groups: Control group, based on amlodipine therapy, the patients received morning valsartan (80-160) mg, qd, n=43 and Observation group, based on amlodipine therapy, the patients received evening valsartan (80-160) mg, qd, n=44. All patients were treated for 8 weeks. Pre- and post-medication BP at day and night were observed by 24h ambulatory BP monitoring, the renal function was measured and the incidence of adverse events was recorded. Results: In Observation group: compared with pre-medication, the average day and night systolic BP (SBP) and diastolic BP (DBP) were decrease at post-medication; compared with Control group, Observation group had the lower night SBP and DBP, P<0.05; the day SBP and DBP were similar between 2 groups after medication. At post-medication, compared with Control group, Observation group presented improved renal function as decreased blood levels of BUN, Cr, β2-MG and increased eGFR, all P<0.05. The incidence of adverse events were similar between Observation group and Control group (6.28% vs 4.65%), P>0.05. Conclusion: Evening medication of amlodipine combining valsartan may effectively control night BP and improve renal function in patients with abnormal nocturnal BP; it didn't elevate the incidence of adverse events.
