Safety study on infusion of PICC intraconazole injection
- VernacularTitle:PICC输注伊曲康唑注射液安全性研究
- Author:
Shuang DONG
;
Xia YAN
;
Jinjin HAN
;
Qian GAO
;
Baohong ZHANG
;
Wei HU
;
Xiaodong XU
;
Lijuan WANG
;
Ziying YANG
- Keywords:
Catheterization,peripheral;
Itraconazole;
Safety
- From:
Chinese Journal of Practical Nursing
2017;33(z1):31-33
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the safety of transfusion of itraconazole through PICC and to evaluate the effect of different amount of blood transfusion before and after the infusion. Methods Patients were recruited from January 1, 2014, until December 31, 2015, in the Hematology hematopoietic stem cell transplantation ward. Thiry-two patients were recruited in the control group. Ninety patients wererecruited in the experience group. They were randomly assigned to three groups with 30 cases each, extracting different amounts of itraconazole before infusion, back phlebotomize in group A, B, C respectively was 10.0, 0.5, 1.0 ml. Comparing the phlebitis and obstruction after ten days from the transfusion day on. Results Catheter obstruction was not observed in any case. There was a significant difference between control group (21.9%,7/32) and observation group (0) regarding the incidence of phlebitis (χ2=21.157,P < 0.05). No statistical difference was noted among the observation groups regarding the incidence of phlebitis (P>0.05). Conclusions Drawing a small amount of blood volume before itraconazole injection through PICC can effectively avoid the drug-induced catheterobstruction. What′s more, transfusion through PICC can significantly reduce the incidence of phlebitis compared with peripheral infusion.
