Efficacy and safety of nalbuphine in preventing the side effect of pruritus induced by intrathecal morphine after cesarean section
10.3760/cma.j.issn.1673-4904.2017.06.009
- VernacularTitle:国产纳布啡预防剖宫产术后鞘内吗啡镇痛瘙痒的效果和安全性研究
- Author:
Zhong QI
;
Yunfei WANG
;
Jiafang WANG
;
Degang ZHU
;
Jin LI
;
Jie WANG
- Keywords:
Pruritus;
Cesarean section;
Nalbuphine;
Morphine;
Injections,spinal
- From:
Chinese Journal of Postgraduates of Medicine
2017;40(6):519-522
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the efficacy and safety of nalbuphine in preventing the side effect of pruritus induced by intrathecal morphine after cesarean section. Methods Sixty patients aged 18- 35 years with ASAⅠ~Ⅱand undergoing cesarean section with combined spinal-epidural anesthesia were randomly and double blindly divided into two groups. Patients in Group N (30 patients) received nalbuphine 4 mg (2 ml) by intravenous route after clamping of the umbilical cord; Patients in Group P (30 patients) received 0.9% NaCl (2 ml) by intravenous route after clamping of the umbilical cord. The protocol of postoperative analgesia was intrathecal morphine 0.2 mg. The patients were followed up for 4 h , and the vital signs were detected at the time of returning to patient s room (T0), 1 h (T1), 2 h(T2), 3 h(T3) and 4 h(T4) after operation. The VAS scores, pruritus severity scores, time of pruritus onset, Ramsay sedation scores and and other adverse effects were recorded. Results The levels of MAP, SpO2, HR in two groups at T0, T1, T2, T3, T4 had no significant differences (P>0.05). The rate of pruritus severity score 0-1 score in group N was significantly higher than that in group P (χ2=17.4, P=0.00). The VAS scores and the rate of drowsiness, nausea, vomiting, shivering and dizziness in two groups had no significant difference (P>0.05). Conclusions Nalbuphine provides a significant reduction of morphine induced pruritus for patients who received intrathecal morphine analgesia after cesarean section.
