Effects of dexmedetomidine sedation on the swallowing reflex

VernacularTitle:右美托咪定镇静对吞咽反射的影响
Author: Xinjie ZHU ; Qinyan YANG ; Qiang CHEN ; Yuquan CHEN
Keywords: Deglutition; Reflex; Dexmedetomidine; Conscious sedation
From: Chinese Journal of Postgraduates of Medicine 2017;40(6):546-548
CountryChina
Language:Chinese
Abstract: Objective To study the effects of dexmedetomidine on the swallowing reflex. Methods Sixty adult volunteers (ASAⅠ-Ⅱ) were randomly divided into two groups, dexmedetomidine sedation group and propofol sedation group respectively. The BIS value was maintained between 60-65 in both groups. Swallowing reflex was induced by water injection in the pharynx at different depths of sedation, and the swallowing movements were observed. Meanwhile, the RR, SpO2 and OAA/S scores were recorded. Results The swallowing reflex existed in dexmedetomidine sedation group when BIS values was maintained at 60, which had significant difference compared with that in propofol sedation group. The RR, SpO2, OAA/S score in dexmedetomidine sedation group also had statistical difference compared with that in propofol sedation group during swallowing reflex test. Conclusions Slow infusion of dexmedetomidine to maintain the BIS value above 60 will not affect swallowing reflex, and can obtain satisfactory hemodynamic stability. It′clinical safety is high.