Correlation of metastasis associated gene-1 and mammalian target of rapamycin expression with clinical pathology in rectal cancer
10.3760/cma.j.issn.1673-4904.2017.05.003
- VernacularTitle:直肠癌组织中转移相关基因-1和哺乳动物雷帕霉素靶蛋白的表达 与临床病理特征的相关性
- Author:
Bin LIU
;
Yunlin YANG
;
Yongna ZHOU
;
Changlin ZHAO
;
Mingzhi REN
;
Aimin GONG
- Keywords:
Rectal neoplasms;
Immunohistochemistry;
Metastasis associated gene- 1;
Mammalian target of rapamycin
- From:
Chinese Journal of Postgraduates of Medicine
2017;40(5):394-398
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of metastasis associated gene-1 (mag-1) and mammalian target of rapamycin (mTOR) in rectal cancer, and its correlation with clinical pathology. Methods The expressions of mag-1 and mTOR in 60 rectal cancer tissue, 30 adenoma tissues and 10 normal rectal tissues were detected by immunohistochemical method, and the correlation between the expression levels and rectal cancer clinical pathologic characteristics was discussed. Results The positive expression rates of mag-1 and mTOR in rectal cancer tissue were significantly higher than those in normal rectal tissue and adenoma tissue:55%(33/60) vs. 1/10 and 27%(8/30), 58%(35/60) vs. 2/10 and 30% (9/30), and there were statistical differences (P<0.05). The expression levels of mag-1 and mTOR in rectal cancer tissue were correlated with carcinoembryonic antigen on admission, degree of cell differentiation, TNM stage, lymph node metastasis and distant metastasis (P<0.01 or<0.05), but had no correlation with age, gender, neoplasm location and neoplasm appearance (P > 0.05). The correlation analysis result showed that the expressions of mag-1 and mTOR were positively correlated in rectal cancer tissue (r=0.730, P<0.01). Conclusions The mag-1 and mTOR may correlate with invasion and metastasis in rectal cancer, and monitoring mag-1 and mTOR expression has a certain value for determining biological behavior of rectal cancer.
