Expression and significance of estrogen receptor- β and tyrosine kinase receptor- B in endometriosis associated ovarian cancer

VernacularTitle:雌激素受体β与酪氨酸激酶受体B在子宫内膜异位症相关卵巢癌中的表达及意义
Author: Xiaomeng LIN ; Xiaohui YU
Keywords: Endometriosis; Ovarian neoplasms; Estrogen receptor beta; Receptor protein-tyrosine kinases
From: Chinese Journal of Postgraduates of Medicine 2017;40(5):471-473
CountryChina
Language:Chinese
Abstract: Malignant transformation of ovarian endometriosis is known as endometriosis associated ovarian cancer (EAOC). However, the carcinogenic pathways by which EAOC develops remained poorly understood, and numerous studies found the risk factors of malignant transformation. Recent studies have provided evidence that estrogen receptor-β(ER-β) can influence the proliferation, motility and apoptosis of ovarian cancer cells. The signal pathway of tyrosine kinase receptor-B (TrkB)/brain-derived neurotrophic factor (BDNF) has a direct relation with the endometriosis, and its anti-anoikis plays a prerequisite role in proliferation of cancer. In the nervous system, estradiol and estrogen receptor can be combined through a variety of ways to promote BDNF/TrkB high expression and activity enhancement. Therefore,the relationship between high-risk factors of malignant transformation and ER-β expression and ER-β and TrkB/BDNF signal pathways need to be explored in EAOC.