The related research of proprotein convertase subtilisin/Kexin 9 inhibitors and dyslipidemia

VernacularTitle:前蛋白转化酶枯草溶菌素9抑制剂与血脂异常的相关研究
Author: Haiyan REN ; Lihong WANG ; Hui CHE
Keywords: Dyslipidemias; Atherosclerosis; Metabolic syndrome X; Review; Proprotein convertase subtilisin/kexin 9 inhibitor
From: Chinese Journal of Postgraduates of Medicine 2017;40(5):474-477
CountryChina
Language:Chinese
Abstract: Proprotein convertase subtilisin/kexin 9 (PCSK9) inhibitor is recently added to the list of effective lipid-lowering drugs in addition to statins, which can reduce low density lipoprotein cholesterol, treat increased low density lipoprotein cholesterol (LDL-C) and atherosclerotic cardiovascular disease (ASCVD) patients. In the past 30 years, the prevalence of dyslipidemia increased significantly. LDL-C characterized dyslipidemia is an important risk factor of ASCVD and a part of metabolic syndrome, which exists before or after or at the same time of the appearance of obesity, diabetes, and glucose intolerance, coronary heart disease and other diseases. Decreasing LDL-C level can significantly reduce the incidence and mortality risk of ASCVD. In this paper, the research on the regulation of dyslipidemia by PCSK9 inhibitors is discussed.