Impact of Ticagrelor on Platelet Aggregation in Patients With Acute Coronary Syndrome After Percutaneous Coronary Intervention
10.3969/j.issn.1000-3614.2017.05.006
- VernacularTitle:替格瑞洛对急性冠状动脉综合征患者经皮冠状动脉介入治疗后血小板聚集功能的影响
- Author:
Xiaoyun WEI
;
Kui CHEN
;
Xin FU
;
Fei HE
;
Yuhua DANG
;
Zhengming JIANG
;
Caina HU
;
Yanan GUO
- Keywords:
Ticagrelor;
Coronary artery disease;
Platelet
- From:
Chinese Circulation Journal
2017;32(5):442-446
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore the impact of ticagrelor on platelet aggregation in patients with acute coronary syndrome (ACS) after percutaneous coronary intervention(PCI). Methods: A total of 98 ACS patients received PCI in our hospital from 2015-01 to 2015-12 were enrolled. The patients were randomly divided into 2 groups: Clopidogrel group, the patients received oral clopidogrel 300mg at first time and then maintained by 75mg/qd, n=48 and Ticagrelor group, the patients received oral ticagrelor 180mg at first time and then maintained by 90mg/bid, n=50. All patients were treated for 12 months.The level of vasodilator stimulated phosphoprotein (VASP) phosphorylation and platelet reactivity index (PRI) at pre-medication and 24h, 7 days and 1 month after PCI were detected; major adverse cardiovascular events (MACE) and bleeding events were recorded within 1 month after PCI, the incidence of platelet aggregation, MACE and bleeding events were compared between 2 groups.Results: The baseline information and PCI condition were similar between 2 groups, P>0.05. The overall average PRI was different between 2 groups, P<0.001 and PRI at each time point was different between 2 groups, P<0.001, different group and time point had interactive effect on PRI, P<0.001. Compared with Clopidogrel group, Ticagrelor group had the lower ratio of PRI≥50% at different time points after PCI, P<0.001. The incidence of MACE and bleeding event were similar between 2 groups within 1 month after PCI, P>0.05. Conclusion: Ticagrelor was superior toclopidogrel for anti-platelet aggregation in ACS patients after PCI, it didn't increase bleeding events.
