Correlation of Lactate Dehydrogenase and Neuron?specific Enolase with Prognosis of Extensive Small Cell Lung Cancer

VernacularTitle:乳酸脱氢酶和神经元特异性烯醇化酶水平与广泛期小细胞肺癌预后的关系
Author: Xi YU ; Xi YU ; Binbin ZHANG ; Bijie YANG ; Zhe ZHANG ; Mingxia MA ; Jiayun ZOU ; Mingfang ZHAO
Keywords: extensive stage; small cell lung cancer; lactate dehydrogenase; neuron?specific enolase; prognosis
From: Journal of China Medical University 2017;46(5):425-428
CountryChina
Language:Chinese
Abstract: Objective To determine whether neuron?specific enolase(NSE)affects the prognosis of extensive small cell lung cancer by analyz?ing the association between NSE before treatment and disease progression and overall survival of patients. Methods This study retrospectively an?alyzed 83 inpatients in the medical oncology department of the First Affiliated Hospital of China Medical University from March 2008 to September 2014. The Kaplan?Meier method and Cox proportional hazards models were used to analyze relevant factors affecting the prognosis of extensive small cell lung cancer;statistical significance was determined for a P value less than 0.05. Results The lactate dehydrogenase(LDH)level be?fore treatment was significantly associated with the progression?free survival(PFS)(P=0.001)and overall survival(OS)(P=0.036). The NSE level before treatment was also significantly associated with the PFS(P=0.007)and OS(P=0.013). Conclusion LDH and NSE affect progno?sis and survival of patients with extensive small cell lung cancer.