Expression and correlation of CTGF, TGF-β1, β-Gal in the primary pulmonary bulla
10.3760/cma.j.issn.1001-4497.2017.04.007
- VernacularTitle:CTGF、 TGF-β1和β-Gal在原发性肺大疱组织的表达及相关性研究
- Author:
Yunan ZHENG
;
Hui LI
;
Jinbai MIAO
;
Shengcai HOU
;
Bin HU
;
Tong LI
;
Yang WANG
- Keywords:
Bulla;
Spontaneous pneumothorax;
Pulmonary fibrosis;
Cell senescence;
Connective tissue growth factor;
Transforming growth factor;
Galactosidase
- From:
Chinese Journal of Thoracic and Cardiovascular Surgery
2017;33(4):222-225
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect the express of the pulmonary fibrosis factor CTGF,TGF-β1 and the senescence correlated β-Gal in the primary pulmonary bulla,and investigate the correlation of the pulmonary fibrosis factor,cell senescence and the development of the primary pulmonary bulla.Methods The expression of CTGF,TGF-β1 and β-Gal protein in the tissue of normal lung tissues and lung bullae were tested.The cell image extracted with the digital camera system was entered into the Image-pro Plus 6.0 morphology Image analysis system and analyzed with Semi-quantitative way.Results The expression level of TGF-β1 and CTGF in primary pulmonary bulla organization was obviously higher than that of normal lung tissue.There was a statistically significant difference(P ＜ 0.05).CTGF and TGF-β1 expression level had a significant correlation (r =0.965,P ＜ 0.01).β-Gal expression level of primary pulmonary bullae had no obvious difference with normal lung tissue.Conclusion CTGF and TGF-β1 may play an important role in the formation of primary pulmonary bulla.Both play a synergistic role in the formation of primary pulmonary bulla.Cell senescence is not relevanted with the formation of primary pulmonary bulla.
