Effect of NF-κB on the pathogenic course of non-alcoholic fatty liver disease
10.11817/j.issn.1672-7347.2017.04.016
- VernacularTitle:NF-κB对非酒精性脂肪性肝病发病过程的影响
- Author:
Li WU
;
Yutao XIE
- Keywords:
non-alcoholic fatty liver disease;
NF-κB;
IκB kinase;
inflammation;
fibrosis
- From:
Journal of Central South University(Medical Sciences)
2017;42(4):463-467
- CountryChina
- Language:Chinese
-
Abstract:
With the economic growth and better standards of living,the prevalence of non-alcoholic fatty liver disease (NAFLD) is expected to increase dramatically worldwide.NAFLD is a common chronic inflammation disease.NF-κB is a transcription factor that plays crucial roles in inflammation,immunity,cell proliferation and apoptosis.It can facilitate the occurrence and development of NAFLD,and the underlying mechanisms are related to insulin resistance,oxidative stress,alteration of intestinal flora,activation ofrenin angiotensin system,etc.
