Advance in glutathione S-transferase kappa 1
10.11817/j.issn.1672-7347.2017.04.017
- VernacularTitle:谷胱甘肽硫转移酶K1研究进展
- Author:
Chun HU
;
Lin SUN
- Keywords:
glutathione S-transferase kappa 1;
mitochondria;
peroxisome;
adiponectin
- From:
Journal of Central South University(Medical Sciences)
2017;42(4):468-475
- CountryChina
- Language:Chinese
-
Abstract:
Glutathione S-transferase kappa 1 (GSTK1) is a key regulator for adiponectin secretion and multimerization.In Caenorhabditis elegans,GSTK1 is involved in energy production and lipid metabolism.Meanwhile,the GSTK1 level is negatively correlated with obesity.It may alleviate the endoplasmic reticulum stress-mediated downregulation of adiponectin.Moreover,a polymorphism in human GSTK1 promoter is related with insulin secretion and fat deposition.Therefore,GSTK1 might be a novel target for the treatment of insulin resistance and the relevant metabolic diseases.
