Diagnostic significance of humoral and cellular immune function detection in patients with syphilis
10.3969/j.issn.1673-4130.2017.09.024
- VernacularTitle:体液免疫和细胞免疫功能检测对梅毒患者的诊断意义
- Author:
Xia YAN
;
Xuelian XIAO
- Keywords:
humoral immunity;
cellular immunity;
syphilis;
diagnosis
- From:
International Journal of Laboratory Medicine
2017;38(9):1222-1224
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate and analyze the diagnostic significance of humoral and cellular immune function detection in the patients with syphilis.Methods Eighty-six cases of syphilis without anti-syphilis treatment in our hospital were selected as the research subjects(syphilis),including 26 cases of primary syphilis,39 cases of secondary syphilis 21 cases of latent syphilis,and 30 healthy subjects were selected as the control group.Then the humoral immunity and cellular immunity levels were compared between the two groups.Results The levels of IgG,IgA and IgM in the syphilis group were significantly increased compared with the control group(P<0.05).The IgG,IgA and IgM levels had no statistical difference between the primary syphilis patients and control group(P>0.05),which in the patients with secondary syphilis and latent syphilis were significantly increased compared with the control group,moreover the increase in the secondary syphilis was most significant(P<0.05);the CD3+,CD4+,CD4+/CD8+ and NK levels in different stages of syphilis were significantly decreased compared with the control group(P<0.05),while the CD8+ level was significantly higher than that in the control group(P<0.05),in which the change in the secondary syphilis patients was most significant.Conclusion The humoral immune in the patients with syphilis is hyperfunction,while cellular immune is dysfunction,the patients present the overall immune function disorder,therefore the humoral and cellular immunity detection has a certain clinical value in the diagnosis of syphilis.
