Effects of dexmedetomidine on the emergence of patients undergoing transnasal transsphenoidal pituitary tumor resection
- VernacularTitle:右美托咪定对经鼻中隔-蝶窦垂体瘤切除术患者苏醒期的影响
- Author:
Shuai TANG
;
Yang XUE
;
Liangyan ZHANG
;
Meng LIANG
;
Kan DENG
;
Yu ZHANG
;
Jie YI
;
Xiuhua ZHANG
;
Yuguang HUANG
- Keywords:
Pituitary tumor resection;
Emergence agitation;
Dexmedetomidine
- From:
The Journal of Clinical Anesthesiology
2017;33(5):446-448
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effect of dexmedetomidine on the tolerance to endotracheal tube, on agitation and other complications of patients undergoing transnasal transsphenoidal pituitary tumor resection.Methods One hundred and twenty-four patients aged 18-65 years, ASA physical status Ⅰ or Ⅱ) were randomly assigned to dexmedetomidine group (group D, n=60) and control group (group C, n=62).Group D were given intravenous infusion of dexmedetomidine during the operation and group C with saline.The extubation time, observation time in the post-anesthesia care unit (PACU), the incidence of emergence agitation, cough, postoperative sore throat and hoarseness were analyzed.Results The extubation time [(29.7±11.5) min vs (22.2±8.5) min] and the length of stay in PACU [(41.5±11.8) min vs (35.3±10.0) min] were significantly longer in group D than those in group C (P<0.05).There was no significant difference of the incidence of emergence agitation (26.3% vs 32.3%), cough (49.1% vs 53.2%), postoperative sore throat (14.0% vs 24.2%) and hoarseness (10.5% vs 19.4%) between two groups.Conclusion Intraoperative intravenous administration of dexmedetomidine can prolong the extubation time and the length of stay in PACU.The incidence of agitation, cough, postoperative sore throat and hoarseness was not affected by dexmedetomidine.
