Investigation on procalcitonin in diagnosis of fever in cancer patients
10.3969/j.issn.1673-4130.2017.09.011
- VernacularTitle:降钙素原在恶性肿瘤患者发热诊断中的研究
- Author:
Fan GUO
;
Yishan HUO
;
Min FENG
;
Yangchun FENG
;
Yanchun HUANG
- Keywords:
procalcitonin;
fever;
tumor;
diagnosis
- From:
International Journal of Laboratory Medicine
2017;38(9):1186-1189
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the application value of procalcitonin(PCT) in fever of the patients with malignant tumor.Methods A total of 254 patients with malignant tumor complicating fever from January to October 2016 were collected and grouped after clearly diagnosing the causes of body temperature increase according to the clinical manifestations,laboratory examination and imaging examination results.The difference of PCT level was compared among various groups.Results Compared with tumor thermal group,the PCT level in the sepsis and non-sepsis groups was significantly increased(P<0.001).Moreover no matter which was bacterial infection,fungal infection or both mixed infection,the PCT level was significantly higher than that in the tumor thermal group;compared with the fungal infection group,the PCT level in the bacterial infection group was increased significantly(P<0.01).The PCT level distribution difference among the tumor thermal group,fungal infection group and bacterial infection group was statistically significant(P<0.01).The critical values of PCT for diagnosing fungal and bacterial infectious fever were 0.575,0.945 ng/mL respectively.The areas under ROC curve were 0.812(95%CI:0.805-0.934);0.951(95%CI:0.917-0.985).Conclusion It is priliminarily considered that PCT can serve as an effective clinical auxiliary diagnostic indicator for differentiating the fever cause in the patients with malignant tumor.
