Clinical study of combined detection of troponin T,myoglobin and NT-ProBNP in diagnosis of myocardia linfarction
10.3969/j.issn.1673-4130.2017.09.023
- VernacularTitle:联合检测肌钙蛋白T及肌红蛋白和NT-ProBNP在心肌梗死诊断中的临床研究
- Author:
Fei SHEN
;
Chengfang ZHANG
;
Juan ZHAO
;
Guangxin CHEN
;
Hui LI
;
Xiaoming LIAO
- Keywords:
troponin T;
muscle hemoglobin;
NT-proBNP;
myocardial infarction
- From:
International Journal of Laboratory Medicine
2017;38(9):1220-1221,1224
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the clinical application of combined detection of troponin T(cTnT),myoglobin(Myo) and NT-ProBNP in the diagnosis of myocardial infarction(MI).Methods A total of 913 cases of acute chest pain complaints to our hospital for examination and treatment from January 2012 to December 2015 were selected and divided into the acute MI group and non-acute MI group according to the final diagnostic results.The cTnT,Myo and NT proBNP levels were detected in all subjects.The differences of cTnT,Myo and NT-proBNP levels were observed in the two groups.The sensitivity and specificity of single indicator detection,2-indicator combined detection and 3-indicator combined detection for diagnosing MI were observed.Results The levels of cTnT,Myo and NT-proBNP in the acute MI group were significantly higher than those in the non-acute MI group,the difference was statistically significant(P<0.05).The sensitivity and specificity of the two-indicator combined detection were higher than those of cTnT,Myo and NT-proBNP single detection,the sensitivity and specificity of the 3-indicator combined detection were 95.18% and 89.86% respectively,which were significantly higher than those of the single indicator test and the two-indicator combined detection.Conclusion The combined examination of cTnT,Myo and NT-proBNP has important significance in the diagnosis of MI,can improve the specificity and sensitivity of MI diagnosis and provides a reliable basis for clinical treatment.
