Subchronic toxicity study of silver nanoparticles on medaka

VernacularTitle:纳米银对青鳉的亚慢性毒性研究
Author: Yanjun ZHOU ; Yang SHI ; Yuan WU
Keywords: silver nanoparticles; medaka; subchronic toxicity
From: Acta Universitatis Medicinalis Anhui 2017;52(5):719-723
CountryChina
Language:Chinese
Abstract: Objective To study the sub chronic toxicity of silver nanoparticles on medaka.Methods Adult fish were divided into silve nenopartides and control group.Animals were collected on 14 days after exposure, and some toxicological endpoints such as death rate, tissue distributed of silver irons, oxidative stress and histopathological damage were measured.Results There were significant difference in death rate of medaka treated with silver nanoparticles and control group.Compared with the control group, the content of silver in gill, intestine and liver of medaka treated with silver nanoparticles were increased significantly.Compared with control group, the activity of LDH in liver and SOD in liver and gill were significantly decreased(P<0.01).The content of MDA in liver of medaka treated with silver nanoparticles was significantly increased(P<0.01).The liver and gill of mekada treated with silver nanoparticles were damaged, compared with control group.Conclusion Nano silver has a certain subchronic toxicity to aquatic life.