Effect of sevoflurane on the electric activities of inhibitory interneurons in basal forebrain area
- VernacularTitle:七氟醚对基底前脑区抑制性中间神经元电活动的影响
- Author:
Ge SONG
;
Haopeng ZHANG
;
Huiming LI
;
Wen LI
;
Haizhi HAO
;
Hailong DONG
- Keywords:
Sevoflurane;
Basal forebrain;
Interneurons
- From:
The Journal of Clinical Anesthesiology
2017;33(5):469-472
- CountryChina
- Language:Chinese
-
Abstract:
Objective To provide new experimental evidences associated with the mechanisms of inhaled anesthetics, the effects of sevoflurane on the electric activities of inhibitory interneurons in basal forebrain area (BF) were observed.Methods C57BL/6 mice, aged 2-3 weeks, were used and BF sections were cut for whole patch-clamp recording.Artificial cerebrospinal fluid containing sevoflurane was given and action potential, inhibitory postsynaptic potential were recorded.Results Sevoflurane could increase the frequency of firing rate of inhibitory interneurons in basal forebrain area (P<0.001), which could increase the frequency of action potential caused by depolarization current (P<0.05), and increase the frequency of spontaneous inhibitory postsynaptic currents of pyramidal neurons (P<0.05), while AP-depended miniature inhibitory postsynaptic currents were not significantly changed.Conclusion The basal forebrain inhibitory interneurons are involved in the anesthetic effect of sevoflurane.
