Recent progress in study onneuroprotection of phosphodiesterase 5 inhibitors
10.3969/j.issn.1001-1978.2017.05.003
- VernacularTitle:磷酸二酯酶5抑制剂的神经保护作用研究进展
- Author:
Fan XU
;
Ming LEI
;
Long LONG
;
Qihai GONG
;
Jianmei GAO
- Keywords:
phosphodiesterase 5 inhibitors;
neuroprotection;
anti-stroke;
anti-neuroinflammation;
anti-oxidation;
amelioration of cognitive deficits;
research progress
- From:
Chinese Pharmacological Bulletin
2017;33(5):603-606
- CountryChina
- Language:Chinese
-
Abstract:
In recent years,the role of phosphodiesterase 5(PDE5)has been highlighted in the development and progression of neurological disease.PDE5 inhibitors show significant effect of neruoprotection,which may be related with some effects such as resistance to stroke,anti-oxidation,inhibition of neuroinflammation and amelioration of cognitive deficits.Based on the domestic and overseas researches about PDE5,this review systematically summarized the neuroprotection of PDE5 and their related mechanisms.
