Relevance of 5-hydroxytryptamine transporter genepolymorphism and chronic obstructive pulmonary disease
10.3969/j.issn.1001-1978.2017.05.018
- VernacularTitle:5-羟色胺转运体基因多态性与慢性阻塞性肺疾病相关性研究
- Author:
Xueqin LI
;
Yunjing LI
;
Weiguo ZHAO
;
Jiongyu MIAO
;
Huailiang WANG
- Keywords:
5-hydroxytryptamine;
5-hydroxytryptamine transporter;
gene polymorphism;
chronic obstructive pulmonary disease;
pulmonary arterial hypertension;
hereditary susceptibility
- From:
Chinese Pharmacological Bulletin
2017;33(5):681-684
- CountryChina
- Language:Chinese
-
Abstract:
Aim To investigate the relevance of 5-hydroxytryptamine transporter(SERT)gene polymorphism and chronic obstructive pulmonary disease(COPD).Methods A total of 51 COPD patients and 49 healthy controls were collected.SERT gene polymorphism and mRNA expression in COPD and control groups were assayed by PCR and real-time PCR,respectively.Lung function was evaluated by a forced expiratory volume in 1 second(FEV1),forced vital capacity(FVC)and FEV1/FVC.Results Two allele gene 484 bp and 528 bp were detected.It consisted of three genotypes L/L(528/528),L/S(528/484)and S/S(484/484),and SS genotype was prevalent in control and COPD group;SERT mRNA expression in COPD group was higher than that in the control;L allele in COPD with PAH patients was higher than the control.The age at diagnosis of COPD in LS genotype patients was earlier compared with that in SS genotype patients.Conclusion SERT gene polymorphism is relevant to hereditary susceptibility of COPD,which may play an important role in the development of COPD,especially promoting PAH in advanced stage of COPD.
