Effects of self-made Yishen Antai Decoction combined with progesterone in the treatment of patients with recurrent spontaneous abortion and the effect on pregnancy outcomes and blocking antibodies
10.3969/j.issn.1005-1678.2017.09.042
- VernacularTitle:自拟益肾安胎方联合黄体酮治疗复发性流产患者的效果及对妊娠结局、封闭抗体的影响
- Author:
Xia LIU
- Keywords:
recurrent spontaneous abortion;
self-made Yishen Antai decoction;
progesterone;
pregnancy outcome;
blocking antibody;
inflammatory factor
- From:
Chinese Journal of Biochemical Pharmaceutics
2017;37(9):104-105,107
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of self-made Yishen Antai Decoction combined with progesterone in the treatment of recurrent spontaneous abortion (RSA) and the effect on pregnancy outcomes and blocking antibodies (BA). Methods 100 cases of patients with RSA were randomly divided into the observation group and the control group, 50 cases in each group. The control group was treated with progesterone and on the basis, the observation group was additionally treated with self-made Yishen Antai Decoction. Both groups were intervened till 12 weeks of gestation, and the clinical curative effect was evaluated. Results The total effective rate of treatment, the success rate of pregnancy and the positive rate of blocking antibody (BA) showed significant differences between the observation group and the control group (P< 0.05). After treatment, the total TCM symptom score and serum levels of interleukin-2 (IL-2) and interferon-γ (IFN-γ) were significantly lower while interleukin-10 (IL-10) level was significantly higher in the observation group than the control group (P< 0.05). There were no serious adverse reactions in the two groups. Conclusion Self-made Yishen Antai Decoction is effective and safe in the treatment of RSA. It can significantly improve the success rate of pregnancy and the positive rate of BA, which may be associated with the regulation of IL-2, IL-10 and IFN-γ levels.
