Research on effect of benazepril treat with diabetic nephropathy on Plasma NO and ET-1

VernacularTitle:贝那普利治疗糖尿病性肾病对血浆NO及ET-1的影响研究
Author: Junyan LI ; Qinqin SI ; Xiaohong NIU
Keywords: diabetic nephropathy; benazepril; NO; ET-1
From: Chinese Journal of Biochemical Pharmaceutics 2017;37(9):161-162,165
CountryChina
Language:Chinese
Abstract: Objective To evaluate the clinical efficacy and effect of benazepril treat with diabetic nephropathy on Plasma NO and ET-1. Methods 100 cases of DN patients were divided into two groups by random number table (50cases), group A with basic treatment, group B increased benazepril. Selected another 50 cases of simple diabetic patients as control group, observed the plasma NO (nitric oxide) and ET-1 (ET-1) levels changes of three groups,and compared the clinical efficacy. Results The levels of NO, ET-1 and Ang II in A group and B group were significantly lower than those in control group (P<0.05); the level of NO in B group was higher than that in group A, and the level of ET-1 and Ang II was lower than that of group A(P<0.05). The total effective rate of B group was 86.00％, which was significantly higher than that of control group 58.00％(P<0.05). Conclusion The clinical application benazepril treat with DN can effectively regulated plasma NO and ET-1 levels, protect the kidneys, and improve the therapeutic effect.