Effect of Short-Term Partial Enteral Nutrition on the Treatment of Younger Patients with Severe Crohn's Disease.
- Author:
Yunkoo KANG
1
;
Seung KIM
;
Sang Yong KIM
;
Hong KOH
Author Information
- Publication Type:Original Article ; Clinical Trial
- Keywords: Crohn disease; Younger age; Partial enteral nutrition; Disease activity; Nutritional status
- MeSH: Adolescent; Crohn Disease/*therapy; *Enteral Nutrition/methods; Female; Humans; Male; Nutritional Status; Prospective Studies; Treatment Outcome
- From:Gut and Liver 2015;9(1):87-93
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND/AIMS: To analyze the effect of short-term supportive temporary partial enteral nutrition therapy for treating severe pediatric Crohn's disease (CD). METHODS: We conducted a prospective, open-label study in pediatric patients with CD (n=78) from January 2007 to December 2011. The CD patients were divided into three groups according to disease severity (mild, moderate, and severe). Seventeen patients with severe CD received short-term partial enteral nutrition (SPEN) in addition to their general diet for 4 weeks after the induction of remission with medical treatment. This SPEN group was further divided into two groups by age (<13 years, > or =13 years). Nutritional parameters and Pediatric Crohn's Disease Activity Index scores were analyzed at the initial enrollment and following 1 year of treatment for all groups. RESULTS: Nutritional status improved substantially after 1 year of treatment in the severe CD group. Nutritional status in the SPEN group improved considerably more than that in the non-SPEN group. Additionally, the <13-year-old group demonstrated better nutritional status improvement than the > or =13-year-old group. CONCLUSIONS: SPEN may be effective in pediatric patients with severe CD for improving nutritional status and moderating disease severity.
