Research progress in the mechanism of telomeric shelterin component TRF2 in tumori-genesis and tumor treatment
10.3969/j.issn.1000-8179.2017.16.325
- VernacularTitle:端粒保护蛋白TRF2在肿瘤发生和治疗中作用机制的研究进展
- Author:
Ru SUN
- Keywords:
telomere;
telomeric shelterin;
telomeric-repeat binding factor 2;
tumor
- From:
Chinese Journal of Clinical Oncology
2017;44(16):835-838
- CountryChina
- Language:Chinese
-
Abstract:
Telomeric-repeat binding factor 2 (TRF2) as an important telomere binding protein, protects telomere ends and maintains the structural and functional stability and integrity of telomeres by interacting with five other essential core proteins (POT1, TRF1,TIN2, RAP1, and TPP1) to form a complex called shelterin. An increasing number of studies have discovered the abnormal expression of TRF2 in many tumors and that TRF2 is closely related to tumor occurrence, drug resistance, and tumor angiogenesis. Here, we review the latest research findings on the structure and function of TRF2, as well as the role of TRF2 in the occurrence, development,and treatment of tumors. We hope to provide novel perspectives for the prevention and treatment of tumors.
