Predictive value of high-sensitivity C-reactive protein to perineonate mortality in early onset severe pre-eclampsia pregnant women
10.3760/cma.j.issn.1673-4904.2017.09.013
- VernacularTitle:高敏C反应蛋白对早发型重度子痫前期孕妇围生儿病死率的预测价值研究
- Author:
Xiaojun FAN
;
Li CHEN
;
Chunhua LIU
- Keywords:
Eclampsia;
C- reactive protein;
Perinatal mortality;
Forecasting;
Retrospective studies
- From:
Chinese Journal of Postgraduates of Medicine
2017;40(9):813-816
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the predictive value of high-sensitivity C-reactive protein (hs-CRP) to perineonate mortality in early onset severe pre-eclampsia (EOSPE) pregnant women. Methods Seventy-five pregnant women with EOSPE (EOSPE group) and 75 pregnant women with gestational hypertension (control group) were selected. The serum tumor necrosis factor (TNF)-α, interleukin (IL)-2 and hs-CRP levels were detected. The data of perineonate death in EOSPE group were recorded, then the pregnant women were divided into death subgroup and survival subgroup. Results The hs-CRP, TNF-αand IL-2 levels in EOSPE group were significantly higher than those in control group:(7.2 ± 2.1) mg/L vs. (2.5 ± 1.0) mg/L, (28.9 ± 5.3) ng/L vs. (12.4 ± 3.5) ng/L and (134.3 ± 34.6) ng/L vs. (104.2 ± 28.5) ng/L, and there were statistical differences (P<0.05). In EOSPE group, 18 perineonates died (death subgroup), and 57 perineonates were survival (survival subgroup). The hs-CRP in death subgroup was significantly higher than that in survival subgroup: (8.9 ± 1.3) mg/L vs. (7.1 ± 1.2) mg/L, and there was statistical difference (P<0.05). But there were no statistical differences in TNF-αand IL-2 between death subgroup and survival subgroup (P>0.05). Receiver operating characteristic curve analysis result showed that the best threshold of hs-CRP for predicting the perineonate mortality caused by EOSPE was 7.98 mg/L, and the area under the curve was 0.779 (95％CI 0.637 to 0.922), with a sensitivity of 0.83 and a specificity of 0.68. Conclusions Inflammatory reaction is involved in the pathophysiological process of EOSPE, and hs-CRP is a good index to predict perineonate death in EOSPE pregnant women.
