Correlation analysis between clinical features and renal dysfunction in patients of acute lacunar infarction with progressive cerebral microbleeds
10.3760/cma.j.issn.1673-4904.2017.09.014
- VernacularTitle:急性腔隙性脑梗死后进展性脑微出血的临床特征及与肾功能减退的相关性分析
- Author:
Qingchun FENG
;
Da HUANG
;
Shaomin HU
;
Biying WU
;
Xingwen WANG
;
Fu LIANG
;
Xiaoli CHEN
;
Meijuan PENG
- Keywords:
Brain infarction;
Cerebral hemorrhage;
Renal insufficiency;
Glomerular filtration rate
- From:
Chinese Journal of Postgraduates of Medicine
2017;40(9):817-820
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the correlation between clinical features and renal dysfunction in patients of acute lacunar infarction with progressive cerebral microbleeds (CMBs). Methods Two hundred and sixty-five patients with first-episode acute lacunar infarction were selected. The serum creatinine was measured within 24 h of admission and the estimated glomerular filtration rate (eGFR) was calculated. The brain MRI (including gradient-echo images) was examined within 2 d of admission and after 1 years of follow-up, respectively. The progressive CMBs was assessed with microbleeds anatomical rating scale (MARS), and the patients were divided into progressive CMBs group (progressive group, 42 cases) and non progressive CMBs group (non progressive group, 223 cases). The clinical features of 2 groups were compared and the correlation between progressive CMBs and renal dysfunction was analyzed. Results The age, 24 h pulse pressure, incidences of renal dysfunction and CMBs in progressive group were significantly higher than those in non progressive group: (69.8 ± 5.8) years vs. (61.5 ± 4.9) years, (63.3 ± 3.1) mmHg (1 mmHg=0.133 kPa) vs. (51.8 ± 4.2) mmHg, 69.0％(29/42) vs. 39.9％(89/223) and 57.1％(24/42) vs. 25.1％(56/223), and the platelet was significantly lower than that in non-progression group:(168 ± 35) ×109/L vs. (189 ± 40) ×109/L, and there were statistical differences (P<0.05 or<0.01). The Logistic regression analysis result showed that renal dysfunction and CMBs were Independent risk factors of progressive CMBs (OR = 1.571 and 1.054, 95％ CI 1.042 - 2.493 and 1.010 - 1.142, P<0.05). Conclusions The rate of renal dysfunction is higher in patients of acute lacunar infarction with progressive CMBs, and progressive CMBs are associated with renal dysfunction.
