Association between optical coherence tomography characteristics and peripheral blood leukocyte count in patients with acute myocardial infarction
10.3969/j.issn.1004-8812.2017.08.002
- VernacularTitle:急性心肌梗死斑块破裂光学相干断层成像特征与外周血白细胞计数的关系
- Author:
Chen LIU
;
Peng ZHOU
;
Zhongwei SUN
;
Yu TAN
;
Jiannan LI
;
Zhaoxue SHENG
;
Jinying ZHOU
;
Hanjun ZHAO
;
Li SONG
;
Hongbing YAN
- Keywords:
Acute myocardial infarction;
Optical coherence tomography;
Plaque rupture;
Peripheral blood leukocyte count
- From:
Chinese Journal of Interventional Cardiology
2017;25(8):422-426
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between optical coherence tomography (OCT) characteristics and peripheral blood leukocyte count in patients with acute myocardial infarction(AMI). Methods A total of 33 patients with AMI hospitalized in Fuwai Hospital for primary percutaneous coronary intervention were consecutively enrolled,and underwent intracoronary OCT procedures after manual aspiration of coronary thrombus. Demographic data, risk factors, procedural and OCT data, past medical history and perioperative laboratory findings were collected in all patients. Results The lymphocyte count,monocyte count and basophil count were significantly higher in the patients with fibrous cap thickness ≥ 65 μm than in those patients with fibrous cap thickness ≤ 65 μm. Patients presenting with cholesterol crystallization had lower eosinophil count than those patients with crystallization-free [(0.04±0.06)×109/L vs.(0.10±0.09) ×109/L,P =0.028]. In addition,the former had significantly higher to neutrophil lymphocyte ratio than the latter [(8.35±6.13)vs.(4.97±2.01), P =0.020]. Higher monocyte count was found in the patients with calcified plaque (P <0.05). Platelet to lymphocyte ratio was significantly increased in the patients with macrophage infiltration [(165.72±85.93)vs.(113.47±19.13),P <0.05]. The leukocyte count,neutrophil count and monocyte count showed the treat of elevation as the number of OCT characteristics increased,but only the elevation of monocyte count had statistical significant level (P = 0.014). Conclusions Peripheral blood leukocyte count seems to be associated with OCT characteristics of plaque rupture in patients with acute myocardial infarction,suggesting the potential role of inflammation in plaque rupture.
