Association between glycated hemoglobin and plaque characteristics in patients with non-ST-elevation acute coronary syndrome

VernacularTitle:急性冠状动脉综合征患者糖化血红蛋白水平与冠状动脉病变特点关系的血管内超声研究
Author: Xin HUANG ; Yongbai LUO ; Haoyu WU ; Fangyuan CHEN ; Yong ZHANG ; Yuan FANG ; Ning GUO
Keywords: Acute coronary syndrome; Glycated hemoglobin; Intravenous ultrasound
From: Chinese Journal of Interventional Cardiology 2017;25(8):427-431
CountryChina
Language:Chinese
Abstract: Objective To explore the association between glycated hemoglobin (HbA1c) level at admission and coronary plaque characteristics under intravenous ultrasound (IVUS) study in patients with non-ST-elevation acute coronary syndrome (NSTE-ACS). Methods 118 patients with NSTE-ACS were divided into the low(HbA1c ≤ 5.6％), medium(HbA1c 5.7％-6.4％)and high(HbA1c ≥ 6.5％)level groups based on admission HbA1c. IVUS was performed in all target lesions. Results As compared with the other two groups, patients with high level HbA1c had higher mean body weight index, higher co-morbidities of diabetes mellitus, dyslipidemia and non-ST-elevation acute myocardial infarction.The high HbA1c level group had more diffuse coronary atherosclerosis ,increased plaque burden and higher rates of positive remodeling, soft plaque and plaque rupture. Conculsions The HbAlc level of admission is associated with plaque vulnerability in NSTE-ACS patients.