ATP-P2X7R signalling pathway and its effects in parasitic diseases
10.16250/j.32.1374.2016250
- VernacularTitle:ATP-P2X7R信号通路及其在寄生虫感染中的作用
- Author:
Wangfang JIANG
;
Chunjie JIANG
;
Fei GUAN
;
Jiahui LEI
;
Ming LUO
- Keywords:
Adenosine triphosphate;
P2X7R;
Macrophage;
Dendritic cell;
Proinflammatory mediator;
Parasitic disease
- From:
Chinese Journal of Schistosomiasis Control
2017;29(4):526-529
- CountryChina
- Language:Chinese
-
Abstract:
ATP (Adenosine triphosphate) is an important endogenous damage-associated molecular pattern (DAMP). P2X7R is an ATP-gated cation channel. ATP-P2X7R plays a vital role in the pathophysiology of many diseases because P2X7R is distributed on various immune cells. ATP-P2X7R signal transduction pathway has been implicated to participate in the body's im-mune defense against pathogens. This paper reviews the recent progress regarding ATP-P2X7R and its effects on parasitic diseas-es.
