Preparation and evaluation of compressive strength and biocompatibilitywith biological calcium citrate cement
10.7652/jdyxb201705010
- VernacularTitle:生物型柠檬酸钙骨水泥的研制及抗压强度和生物相容性评价
- Author:
Xing DAI
;
Qingchun CAI
;
Chihua GUO
;
Xuezhe HAN
;
Wei MA
;
Lu YAO
- Keywords:
calcium citrate;
α-TCP;
bone cement;
biocompatibility
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
2017;38(5):674-678
- CountryChina
- Language:Chinese
-
Abstract:
Objective To produce the biological calcium citrate cement with fresh oyster shells, and investigate its compressive strength and biocompatibility so as to provide the experimental basis for clinical application of the material.Methods The compressive strength of biological calcium citrate cement was measured and its surface morphology was observed by SEM.The calcium release curve and pH value were measured in the simulated body fluid.Last, its biocompatibility was detected by cytotoxicity test.Results Biological calcium citrate cement produced by 0.33mL/g liquid solid ratio had the maximum compressive strength, and the crystal structure of the material was uniform and orderly.The determination of pH value showed that the degradation and absorption of biological calcium citrate cement did not significantly change the pH value of the body fluid.With gradual degradation of the material, the concentration of Ca2+ in the solution increased gradually.Cytotoxicity test showed that this material had good biocompatibility and no cytotoxicity.Conclusion Biological calcium citrate cement possesses strong compressive strength and good biocompatibility, and it can form a microenvironment with low in alkaline and high in calcium.
