Expressions of TREM-1 and COX-2 in rectal carcinomaand their relationship with prognosis
10.7652/jdyxb201705020
- VernacularTitle:TREM-1和COX-2在直肠癌组织中的表达及其与预后的关系
- Author:
Rui ZHANG
;
Huixia CUI
;
Xu YANG
;
Xiaopeng WANG
;
Wenlu ZHANG
- Keywords:
rectal cancer;
triggering receptor expressed on myeloid cells-1 (TREM-1);
cyclo-oxygenase-2 (COX-2);
prognosis
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
2017;38(5):720-724
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect the differences of triggering receptor expressed on myeloid cells-1 (TREM-1) and cyclo-oxygenase-2 (COX-2) expressions in rectal cancer tissues and carcinoma adjacent tissues so as to explore the relationship between the two factors and clinical pathological characteristics and their effects on the patients` survival.Methods The expressions of TREM-1 and COX-2 were analyzed in 68 cases of rectal cancer tissues and 58 cases of carcinoma adjacent tissues with the method of immunohistochemical staining.We made a regular follow-up of the patients, analyzed the relationship between the two factors and prognosis of rectal cancer.Results The positive expression rates of TREM-1 and COX-2 in rectal cancer tissues were higher than those in carcinoma adjacent tissues (P<0.05).The expression of TREM-1 was related to lymph node metastasis, while COX-2 was related to pathological stage and lymph node metastasis (P<0.05).However, the two factors were not related to age, sex, histological differentiation or tumor size.The expressions of the two factors were positively correlated (r=0.550, P<0.001).The overall survival (OS) of TREM-1 and COX-2 positive expression groups was shorter than that of the negative groups (P<0.05).Cox multiple regression analysis showed that the expression of TREM-1, pathological stage, lymph node metastasis and tumor size affected the prognosis.Conclusion The expressions of COX-2 and TREM-1 in rectal cancer increase, suggesting that the two factors may promote the development and lymph node metastasis of rectal cancer, and the expressions of the two factors are related to the patients` poor prognosis.
