Research of serum myoglobin detection in patients with Kennedy's Disease
- VernacularTitle:肯尼迪病患者血清肌红蛋白水平的研究
- Author:
Haixiao GUO
;
Ming LU
;
Dongsheng FAN
- Keywords:
Kennedy`s disease;
spinal and bulbar muscular atrophy;
amyotrophic lateral sclerosis;
myoglobin
- From:
Journal of Clinical Neurology
2017;30(4):294-296
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the significance of serum myoglobin detection in the diagnosis and evaluation of Kennedy`s disease (KD).Methods The level of serum myoglobin (Myo) was detected in 60 KD patients and 30 amyotrophic lateral sclerosis (ALS) patients.Results The serum Myo level and abnormal rate in KD group were significantly higher than those in ALS group (all P<0.001).The serum Myo level was positively related with the disease course of KD (r=0.665,P<0.01).There was no significant difference of serum Myo level and disease course of ALS (r=-0.047,P>0.05).There was no overlap of serum Myo level between the two groups.There was no significant difference of serum Myo level and CAG repeated number of ALS (r=-0.193,P>0.05).Conclusion Myo is likely as an easy and sensitive biomarker, used to identify the KD and special type of ALS, and used in the evaluation of the KD condition in the future.
