Intestinal Absorption of Roxatidine Acetate Hydrochloric in Rats
10.3870/j.issn.1004-0781.2017.08.003
- VernacularTitle:盐酸罗沙替丁醋酸酯在体大鼠肠吸收
- Author:
Lu SUN
;
Yishan DUAN
;
Xueyi LI
;
Ning LIN
- Keywords:
Roxatidine acetate,hydrochloric;
Absorption kinetics;
Intestinal absorption;
Double wavelength spectrophotometry
- From:
Herald of Medicine
2017;36(8):853-856
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore absorption kinetics of roxatidine acetate hydrochloric (ROX) in intestine of rats.Methods The absorption kinetics and permeability of ROX under different concentrations and different intestinal segments were investigated by double wavelength spectrophotometry via the in situ perfusing method in rats.Results There was no significant difference in Ka of ROX under different concentrations.The absorption rate in rats descended in order of duodenum,jejunum,ileum and colon [(3.87±0.12)×10-2,(2.53±0.18)×10-2,(1.43-±0.10)×10-2,(0.91±0.15)×10-2 · h-1].Conclusion The absorption of ROX in intestine complies with the passive transport mechanism and first order kinetics.ROX is well absorbed in thewhole intestine.
